Analytical Development Scientist/Sr. Scientist – Flow Cytometry

About the job

At Syncopation Life Sciences, upending the status quo is in our DNA. We combine a deep understanding of CAR T resistance with a vision of transforming peoples’ lives through the development of next generation cell therapies that provide deeper and more durable responses to a growing number of patients.

Syncopation is an exciting biotechnology company founded by Crystal Mackall and Robbie Majzner to develop next generation CAR T cell therapies designed to achieve superior efficacy by pre-empting important drivers of drug resistance. Our lead program includes a differentiated and clinically validated CD22 CAR that is in clinical development for patients with B-cell malignancies. To help move this and other programs forward, Syncopation has brought together a passionate and seasoned team to develop a focused portfolio strategy. Our team is based in San Mateo, California.

Join us to help make a difference.

Position Summary

Syncopation is hiring an Analytical Development Scientist/Sr. Scientist skilled in flow cytometry-based assay development for cell therapy products. The AD Scientist/Sr. Scientist will lead development studies to establish flow cytometry-based assays for phenotypic characterization, lot release and stability testing of Syncopation’s cell therapy products. We seek a highly motivated individual who possesses a technical understanding of analytical development for cell therapy products and can manage multiple development activities simultaneously.

The successful candidate will work closely with the Process Sciences team and the broader CMC team to support the development of analytical methods for testing and release of Syncopation’s cell therapy products. The individual will also collaborate cross-functionally to ensure timely development and manufacture, and release of drug products as well as support regulatory submissions. The role is based in San Mateo, CA.

What You’ll Do at Syncopation

  • Develop and optimize multicolor, flow cytometry-based assays for Syncopation’s T cell therapy products. Plan, execute, analyze, and communicate data internally and to external stakeholders
  • Provide analytical support for technical development studies performed both internally and externally
  • Establish tracking and trending analyses of process development and cGMP production runs including evaluation of critical reagents, support analytical comparability efforts, evaluation of lot-to-lot variability for key raw materials in order to improve process standardization and assay variability
  • Support analytical method transfer to external testing partners and/or QC at external contract manufacturing organization
  • Participate in laboratory set up, equipment procurement, and establish internal process development practices
  • Author relevant documentation (protocols, technical development, qualification reports)
  • Effectively communicate data to internal stakeholders and external partners
  • Interface and work collaboratively with CDMO and testing lab partners
  • Proactively enable cross-functional collaborations with internal stakeholders, external partners, and consultants.
  • Evaluate emerging technologies and platforms for application in product pipeline development

The Right Stuff

Preferred Qualifications:

  • PhD, Master’s with 5 plus years, or B.S./M.S. with 7 plus years of industry experience. Degree in a relevant scientific area such as biotechnology, bioprocess, molecular biology, immunology, biochemistry (required)
  • Experience in working with multidisciplinary teams. Experience working in a small biotech/start up environment is a plus.
  • At least 2-3 years of prior experience in flow cytometry panel design as well as developing, qualifying (per ICH guidelines), and transferring multi-color flow-based assays
  • At least 2-3 years of prior experience in cell therapy and/or analytical development
  • Expertise in cell-based assays (cytotoxicity, cytokine release, proliferation) a plus
  • Experience with GMP requirements and interfacing with QC, external collaborators, outsourced testing laboratories highly desired.
  • Independently motivated, excel at driving execution, detail oriented, creative approach to problem solving, and adept at working in a fast-paced environment
  • Must have interpersonal, organizational, written, and verbal communication skills, and the ability to work collaboratively in a team environment
  • Proficiency in Office, Design of Experiments, JMP, Prism, and other productivity and data analysis tools is a plus

EEO & Employment Eligibility

Syncopation Life Sciences, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Syncopation Life Sciences, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requires of applicable law.

Syncopation Life Sciences requires all new hires to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Syncopation, and it applies regardless of whether the position is located at a Syncopation site or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.