Scientist/Sr Scientist, Discovery Research

About Syncopation Life Sciences

Syncopation Life Sciences is an adoptive cell therapy company recently launched by Samsara BioCapital in partnership with founders from Stanford University. We are developing novel, CAR T-based technologies and programs to address important drivers of resistance to first-generation cell therapies. The company is based in the San Francisco Bay Area, where we are building a team of talented organization of scientists and drug developers to bring a new generation of cell therapies to the clinic.

Job description

Syncopation is seeking a Scientist or Senior Scientist to design and conduct pre-clinical in vitro experiments to evaluate novel CAR-T therapy candidates. Through their experimental work, the candidate will help to select our earliest candidate therapies and thereby guide the trajectory of this early phase company.

Responsibilities

  • Design and conduct experiments to compare the tumor killing capacity and phenotype of early phase CAR-T cell products
  • Employ broad array of in vitro experimental techniques and technologies
  • Document experimental protocols and results
  • Present research findings at internal meetings
  • Collaborate with team members and train and mentor new team members as needed
  • Keep current with relevant scientific literature
  • Other responsibilities as needed

Qualifications

  • Ph.D in immunology, molecular biology, biochemistry, or related field OR B.S. or M.S. with 4-6+ years relevant work experience (preferred experience with developing cell therapies)
  • Scientific expertise with immunology (focus on T cell signaling), cell therapy development (focus on CAR-T), and/or cancer biology
  • Technical expertise with gene editing (shRNA, CRISPR); molecular biology; mammalian cell culture, transfection, and in vitro tumor killing assays; non-replicative viral vector design, production, and transduction; flow cytometry; kinetic monitoring of cell viability (Incucyte); cytokine assays
  • Detail-oriented in conducting and recording experiments
  • Effective communication skills
  • Innovative, collaborative, flexible, and focused
  • Must be authorized to work in the U.S.

Please apply at: careers@syncopationlife.com